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王敏,俞诗源,刘小媛,曹力凡.2014.X射线辐射对小鼠肾组织结构和血清肌酐与尿素氮含量的影响.动物学杂志,49(4):476-482.
X射线辐射对小鼠肾组织结构和血清肌酐与尿素氮含量的影响
Effects of X-ray on Kidney Histological Structure, Content of Cr and BUN in Blood
投稿时间:2013-11-18  修订日期:2014-07-14
DOI:10.13859/j.cjz.201404002
中文关键词:  X射线  小鼠    组织结构  肌酐  尿素氮
英文关键词:X-ray  mice  kidney  Histological structure  Cr  BUN
基金项目:甘肃省自然科学基金项目(No. 1107RJZA141),兰州市社会发展项目(No. 2013-3-72)
作者单位E-mail
王敏 西北师范大学生命科学学院 wangmin8622@163.com 
俞诗源 西北师范大学生命科学学院 syyu006@nwnu.edu.cn 
刘小媛 西北师范大学生命科学学院  
曹力凡 西北师范大学生命科学学院  
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中文摘要:
      为了探究X射线辐射对小鼠肾组织结构及功能的影响,对96只成体小鼠,用不同剂量(0,1,3,5GY)的X射线进行全身辐射,分别于辐射后5、10、15、20d,称量检测各期小鼠的肾重、用生物显微技术观察肾脏组织结构的变化,,用仪器分析法检测血清肌酐和尿素氮含量的变化。结果显示经X射线辐射后小鼠肾重有不同程度的增加,且与剂量呈正相关,血清尿素氮和肌酐含量均有不同程度的升高(P<0.05或P<0.01),肾脏组织结构损伤明显,肾小球严重肿胀,近曲小管、远曲小管上皮细胞空泡化、凋亡、坏死,小管结构紊乱、官腔结构无法分辨。结果表明X射线辐射严重影响肾的组织结构与功能。
英文摘要:
      To explore the effects of X-ray on mouse kidney tissue structure and function,96 mice were irradiated with different dosages (0,1,3,5Gy) of X-ray. At 5、10、15、20 d after irradiation, Changes of kidney weight were examination,kidney-histological structure was observed using bio-microscopy,and content of BUN、Cr in blood were detected by instrument analysis. The results showed that the kidney weight increased in varying degrees,and correlated with the dose,content of BUN、Cr in blood also increased in varying degrees(p<0.05orp<0.01),kidney-histological structure damaged obviously,glomerular was severe swelling;The proximal tubule,distal convoluted tubule epithelium was vacuolization, apoptosis,and necrosis,The tubule structure was disordered and bureaucratic structure could not distinguish. The phenomenon revealed that X-ray radiation seriously affected the tissue structure and function of the kidney.
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