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韩冰,王荻,卢彤岩.2015.烟酸诺氟沙星在松浦镜鲤体内的药动学特征.动物学杂志,50(1):103-111.
烟酸诺氟沙星在松浦镜鲤体内的药动学特征
Pharmacokinetics of Norfloxacin Nicotinate in Songpu Mirror Carp(Cyprinus carpio specularis)
投稿时间:2014-04-14  修订日期:2014-10-30
DOI:DOI: 10.13859/j.cjz.201501013
中文关键词:  烟酸诺氟沙星  松浦镜鲤  药动学
英文关键词:Norfloxacin nicotinate  Songpu mirror carp(Cyprinus carpio specularis)  Pharmacokinetics
基金项目:公益性行业(农业)科研专项经费(No. 201203085),现代农业产业技术体系建设专项资金(No. CARS-46)
作者单位E-mail
韩冰 上海海洋大学水产与生命学院中国水产科学研究院黑龙江水产研究所 h_bing1022@163.com 
王荻 中国水产科学研究院黑龙江水产研究所  
卢彤岩 中国水产科学研究院黑龙江水产研究所 lutongyan@hotmail.com 
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中文摘要:
      结合单纯聚集法和二步法,应用高效液相色谱(HPLC)技术研究了分别以10、30、60 mg/kg剂量对松浦镜鲤(Cyprinus carpio specularis)口灌烟酸诺氟沙星后,药物在实验鱼血浆中的药动学特征。结果显示,3种给药剂量下,诺氟沙星在松浦镜鲤血浆中的血药浓度和时间关系均可用一级吸收二室开放模型进行描述,吸收半衰期(t1/2ka)分别为0.165、0.061、0.043 h,消除半衰期(t1/2β)分别为18.282、29.969、42.051 h,达峰时间(Tmax)分别为0.333、0.327、0.302 h,达峰浓度(Cmax)分别为4.780、6.247、12.689 mg/L,药时曲线下面积(AUC)分别为32.698、53.015、174.998 mg·h/L,表观分布容积(Vd)分别为1.044、4.347、4.561 L/kg。说明随着给药剂量的增加,诺氟沙星的吸收和消除速率均加快,给药剂量对药动学特征有显著影响。
英文摘要:
      Pharmacokinetics of norfloxacin nicotinate in Songpu mirror carp(Cyprinus carpio specularis)was studied in this experiment. To integrated mere aggregation method and two-step method, fify-four Songpu mirror carp were divided into three groups randomly and oral administed of norfloxacin nicotinate in a single dose of 10, 30, 60 mg/kg, respectively. Then fish in each dose group were divided into three groups, and blood was collected at 0.25, 0.5, 0.75, 1, 1.5, 2, 4, 6, 8, 12, 24, 36, 48, 72 h after administration alternately, fish were kept alive during the whole process. The concentration of norfloxacin was determined by high performance liquid chromatography (HPLC), and the pharmacokinetics of norfloxacin nicotinate in plasma of Songpu mirror carp was analysed by 3p97. The results showed that R2 approached 1 in the norfloxacin concentration range of 0.1 to 100 mg/L (Fig.2), the average recovery was ranged from 97.26% to 99.06% in different concentrations (Table 1). After a single oral administration of three doses respectively, the concentrations versus time of norfloxacin in plasma (Fig.3) were all well described by two-department open model with first-order absorption. The absorption half-lives (t1/2ka) were 0.165, 0.061, 0.043 h, respectively; the elimination half-lives (t1/2β) were 18.282, 29.969, 42.051 h, respectively; the peak times (Tmax) were 0.333, 0.327, 0.302 h, respectively; the maximum content (Cmax) were 4.780, 6.247, 12.689 mg/L, respectively; the area under concentration-time curve (AUC) were 32.698, 53.015, 174.998 mg·h/L, respectively; the apparent volume of distribution (Vd) were 1.044, 4.347, 4.561 L/kg, respectively (Table 2). The results showed that with the increase of dose, the absorption and elimination rate of norfloxacin was accelerated, the pharmacokinetic characteristics were significantly influenced by dosage.
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