Abstract: In order to clarify the possible patterns of haemopoiesis in Ya-fish (Schizothorax prenanti), the method of Wright’s, Periodic acid-schiff (PAS) and Sudan back B (SBB) staining were used in the head kidney, trunk kidney, spleen and liver imprints.The present study were helpful to understand the location and process of haemopoiesis in Ya-fish.The data analysis was performed by the software of Microsoft Excel 2010 and all shown as mean±SD.(standard deviation).The results showed that haemopoiesis had the following series: erythropoiesis, granulopoiesis, monopoiesis and lymphopoiesis, consisted of precursor, young and mature stages. According to the morphology, size and proportions of blood cell lineages, monoblasts were the largest in the one of precursors and the size was about (18.90±1.59) μm× (16.32±0.70)μm(Table.1). Proerythroblasts and monoblasts were the predominant cells in head kidney, accounting for 0.64% and 0.59%, respectively. Granuloblasts and lymphoblasts were regularly present in trunk kidney and spleen, rare in liver(Table.1).Furthermore, thrombocytes were observed in four tissues imprints and macrophagocyte could be discovered in liver(Fig.1). So haemopoietic tissue was found mainly in head kidney, trunk kidney and spleen and a small amount occurred in liver. In the granulocytes lineage, except the blast cells, the young and mature cells were PAS-positive; with the maturation process of monocytes, staining intensity of PAS-positive was increased; lymphocytes, granulocytes and monocytes were SBB-positive, and there was a difference of staining intensity in immature stage cells, the mature cell stained intensely with SBB(Fig.2).During maturation process of erythropoiesis, two trends in size were distinguished:two decreasing and one increasing; otherwise gradual chromatin condensation and the increase in haemoglobin content were observed.The morphological changes of granulopoietic and lymphopoiesis were a constant decrease in size during maturation(Fig.3).