| 潘巧琳,唐燕红,谢静,谢惠春,李金钢,何建平.2015.常氧条件下高原鼢鼠、甘肃鼢鼠及SD大鼠血液理化特征比较.动物学杂志,50(6):839-845. |
| 常氧条件下高原鼢鼠、甘肃鼢鼠及SD大鼠血液理化特征比较 |
| The Comparison of Blood Physicochemical Characteristics between Plateau Zokor (Myospalax baileyi), Gansu Zokor (M. cansus) and SD Rat (Rattus norvegicus) under Normal Oxygen Condition |
| 投稿时间：2015-01-06 修订日期：2015-05-10 |
| DOI：DOI: 10.13859/j.cjz.201506003 |
| 中文关键词: 低氧 甘肃鼢鼠 高原鼢鼠 血气 酸碱特性 电解质 |
| 英文关键词:Hypoxia Gansu zokor (Myospalax cansus) Plateau zokor (M. baileyi) Blood gas Acid-base properties Electrolyte |
| 基金项目:国家自然科学基金资助项目（30670360） |
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| 中文摘要: |
| 为探讨不同低氧环境适应动物的血液理化特征，用美国雅培手掌血气分析仪分别测定常氧适应4周的高原鼢鼠（Myospalax baileyi）及甘肃鼢鼠（M. cansus）的血液的血气、酸碱及电解质指标，并与SD大鼠（Rattus norvegicus）进行比较。结果显示，常氧适应后，甘肃鼢鼠与高原鼢鼠动（PaO2）、静脉氧分压（PvO2），动静脉氧分压差（PaO2﹣PvO2），动（SaO2）、静脉氧饱和度（SvO2）及氧利用率均无显著性差异，两种动物静脉血的氧分压和氧饱和度均极显著低于SD大鼠，氧利用率极显著高于SD大鼠；高原鼢鼠与甘肃鼢鼠动、静脉血红蛋白（Hb）及动、静脉红细胞压积（HCT）无显著性差异，血红蛋白含量与SD大鼠无显著性差异，但红细胞压积（HCT）极显著低于SD大鼠；高原鼢鼠和甘肃鼢鼠血液酸碱特征趋于一致，不同于SD大鼠，动静脉pH差（pHa﹣pHv）及动静脉CO2总含量差（TvCO2﹣TaCO2）显著高于SD大鼠，动脉二氧化碳分压（PaCO2）极显著低于SD大鼠，动静脉二氧化碳分压差（PvCO2﹣PaCO2）极显著高于SD大鼠；高原鼢鼠和甘肃鼢鼠血浆中钠离子（Na+）浓度、钾离子（K+）浓度、游离钙离子（iCa2+）浓度及动静脉钠离子浓度差（Na+v﹣Na+a）、钾离子浓度差（K+v﹣K+a）和游离钙离子浓度差（iCa2+v﹣iCa2+a）无显著性差异；高原鼢鼠动脉血钾离子浓度显著低于SD大鼠，钾离子浓度差显著高于SD大鼠；甘肃鼢鼠钾离子浓度差及动、静脉血钙离子浓度显著高于SD大鼠。这些结果说明，低氧适应动物血气、酸碱及电解质特征一致，与地面生活的SD大鼠差异很大，表现出较低的红细胞压积和较高的氧利用率，血液能耐受较宽范围的酸碱变化，维持电解质稳定，保证内环境稳态。 |
| 英文摘要: |
| In order to investigate the blood gas, acid-base balance and electrolyte characteristics of blood in subterranean rodents under normal oxygen condition, these parameters were messured by the i-STAT blood gas analyzer in Gansu zokor (Myospalax cansus), Plateau zokor (Myospalax baileyi) and SD Rat (Rattus norvegicus) which had adapted at normal oxygen condition for 4 weeks. The comparison of difference between groups were analyzed with one - way ANVOA method using SPSS 17.0. The research showed that there were no significant difference of PaO2, PvO2, PaO2-PvO2, SaO2, SvO2 and oxygen utilization rate between Gansu zokor and Plateau zokor. Their PvO2 and SvO2 were significantly lower than that in SD Rat, but oxygen utilization was significantly higher than that in SD Rat. There were no significant difference of Hba, Hbv, HCTa and HCTv between Gansu zokor and Plateau zokor. But their HCTa and HCTv were significantly lower than that in SD Rat (Table 1). Blood acid-base characteristics in Gansu zokor and Plateau zokor were different from SD Rat, but the characteristics in Gansu zokor and Plateau zokor were similar. pHa-pHv, TvCO2-TaCO2 in Gansu zokor and Plateau zokor were higher than that in SD Rat. PaCO2 in Gansu zokor and Plateau zokor was significantly lower than that in SD Rat. PvCO2-PaCO2 in Gansu zokor and Plateau zokor was significantly higher than that in SD Rat (Table 2). There were no significant difference of Na+, K+, iCa2+, Na+v-Na+a, K+v-K+a and iCa2+v-iCa2+a in Gansu zokor and Plateau zokor. K+a in Plateau zokor was lower than that in SD Rat, but K+v-K+a in Plateau zokor was higher than that in SD Rat. K+v-K+a, iCa2+a and iCa2+v in Gansu zokor were higher than that in SD Rat (Table 3). The result prompted that the blood gas characteristics, acid-base balance and electrolyte characteristics in Gansu zokor and Plateau zokor were similar, but they are different from SD Rat. The oxygen utilization rate in Gansu zokor and Plateau zokor were higher than that in SD Rat. In order to guarantee internal environment and homeostasis, Gansu zokor and Plateau zokor had strong tolerance to acid-base variation and maintenance to electrolyte stability. |
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