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黄卫红.2018.PRM谱特征作为分子标签评估精子质量的研究.动物学杂志,53(5):781-787.
PRM谱特征作为分子标签评估精子质量的研究
The Study on Protamine Pattern as a Molecular Marker of Sperm Quality
投稿时间:2018-07-03  修订日期:2018-08-21
DOI:10.13859/j.cjz.201805013
中文关键词:  辅助生殖  精蛋白谱特征  男性不育  精子  精蛋白值
英文关键词:Assisted reproductive technology  Protamine (PRM) pattern  Male infertility  Sperm  Protamine (PRM) value
基金项目:国家重大科学研究计划项目(No. 2012CB944900)
作者单位E-mail
黄卫红 中国科学院遗传与发育生物学研究所分子发育生物学国家重点实验室 北京 100101 hwh1216@126.com 
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中文摘要:
      不孕不育症已成为严重的健康问题,全世界约有15%的育龄夫妇患有这一疾病。辅助生殖技术(ART)和精准医疗是解决这一问题的关键,评估人类精子质量是其中的一个重要环节,但是现行世界卫生组织(WHO)标准诊断手册(第5版)具有不确定性。为了提高评估精子质量的精准性,在本研究中,基于精蛋白(PRM)谱特征和PRM值的评估人类精子质量的新方法,对临床上的病例进行了检测。分析结果表明,运用新方法的精子评估结果与临床结局相一致,优于WHO标准(第5版)的检测结果。这一前瞻性的研究工作对于ART和精准医疗有实际意义:能够在临床应用中提高其成功率和增强其安全性。
英文摘要:
      Infertility is a serious reproductive health problem affecting family well-being and harmonious development in our country; globally, around 15% of heterosexual couples are unable to conceive their children without assistance. Assisted reproductive technology (ART) and precision medicine are key to resolve this problem, in which evaluation of sperm quality is necessary and important. However, the world health organization (WHO) laboratory manual for the examination and processing of human semen (fifth edition, 5th) just provides a rough analysis to evaluate human sperm, which brings inconsistency in clinic. How to precisely evaluate human sperm is an imminent and very challenging problem. In this study, a method in terms of protamine (PRM) pattern and value to evaluate human sperm was established. The primary result obtained by using of this new method is consistent with clinical outcome and better than that obtained by using WHO standard manual (5th). Thus, this study is valuable to ART and precision medicine, which can improve ART success rate and safety in clinic.
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