The discontinuous polyacrylamide gel electrophoresis (PAGE) was used to analyze and compare the activities of superoxide dismutase (SOD) and peroxidase (POD) in six tissues and organs including heart, liver, kidney, muscle, brain and lung of Apodemus agrarius and A. peninsulae. SOD and POD were expressed in all six tissues and organs analyzed, but both enzymes showed their specific characteristics in different tissues or organs of Apodemus agrarius and A. peninsulae. A total of 9 polyacrylamide gel electrophoresis bands with a mobility of 0.15 to 0.66 were separated for SOD, while 20 bands with a mobility of 0.09 to 0.83 were separated for peroxidase. Strongest activities of the two enzymes were found in the liver and lung. The activities of SOD in 6 tissues and organs of A. agrarius were stronger than in A. peninsulae. The activities and distribution of POD in the six tissues and organs of A. agrarius and A. peninsulae were similar. However, there were significant differences in POD activity and distribution among tissues and organs in the same species.