冷暴露对中缅树鼩褐色脂肪组织中解偶联蛋白1含量的影响
DOI:
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

基金项目:

国家自然科学基金项目(No.30560026);云南省科技强省研究重点项目(No.2007C000Z1)


The Effects of Cold Exposure on the Content of Uncoupling Protein of BAT in Tupaia belangeri
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    自备抗血清采用酶联免疫法测定了中缅树鼩(Tupaiabelangeri)在(5±1)℃冷暴露0d、7d、14d、21d、28d时,褐色脂肪组织(BAT)中解偶联蛋白1(UCP1)的含量。结果表明,随着冷暴露时间的延长,中缅树鼩的体重、褐色脂肪组织重量均表现出了增加的趋势,BAT线粒体总蛋白和UCP1的含量也呈增加的趋势,其中UCP1的含量在28d时达到极显著水平,比对照组增加了55.9%。说明冷暴露能够诱导中缅树鼩UCP1表达增加,从而使其适应性产热增加。

    Abstract:

    Uncoupling proteins(UCPs) increase proton leakage across the inner mitochondrial membrane.UCP1 in brown adipose tissue dissipates proton motive force as heat.This mechanism of nonshivering thermogenesis is considered as a monophyletic trait of endothermic placental mammals and provided a crucial advantage for life in the cold.Thereby,UCP1 is thus the only protein capable of mediating cold-acclimation-recruited adaptive adrenergic nonshivering thermogenesis.In this study,the content of UCP1 in BAT in Tree Shrews(Tupaia belangeri) was measured during cold exposure for 0 day,7 days,21 days and 28 days by enzyme-linked immunosorbent assay.The body weight,BAT weight,mitochondrial protein contents and UCP1 contents greatly increased with the cold exposure.The UCP1 content increased by 55.9%(P<0.01) significantly after 28 days cold acclimation.The changes in BAT thermogenic properties are important for the survival under cold stress in T.belangeri.

    参考文献
    相似文献
    引证文献
引用本文

谢静,王政昆,张武先,朱莉萍.2008.冷暴露对中缅树鼩褐色脂肪组织中解偶联蛋白1含量的影响.动物学杂志,43(4):34-40.

复制
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2007-12-26
  • 最后修改日期:2008-04-28
  • 录用日期:
  • 在线发布日期:
  • 出版日期: