| 张继荣,雷富民.2008.我国部分禽流感病毒H5N1之HA序列变异演化分析.动物学杂志,43(6):10-16. |
| 我国部分禽流感病毒H5N1之HA序列变异演化分析 |
| Analysis of HA Gene's Variation and Evolution in Some Avian Influenza Viruses from China |
| 投稿时间：2008-05-19 修订日期：2008-09-05 |
| DOI： |
| 中文关键词: 禽流感H5N1病毒 HA基因 变异 |
| 英文关键词:Avian influenza H5N1 HA gene Variation |
| 基金项目:中国科学院三期创新领域前沿项目(No.KSCXZ-YW-N-063);国家科技部十一五平台课题(No.2006BAD06A01);美国NIH、USDA;加拿大IDRC的项目部分资助 |
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| 中文摘要: |
| 从GenBank上获得我国人(Homo sapiens)、家禽和野鸟42株H5N1亚型禽流感病毒的HA基因核酸序列,利用DNAStar分析HA蛋白关键位点氨基酸残基的变化,比较HA基因核苷酸序列同源性,构建遗传进化树。探讨我国部分人、家禽和野鸟H5N1病毒基因的遗传进化关系。序列分析结果表明:禽流感病毒H5N1亚型的HA基因持续地发生着变异,但并非以均一速度进行,时间间隔愈长,核苷酸同源性愈低;我国同一地区或临近地区,当年或前后两年发生的人及家禽感染的禽流感病毒高度同源。推测我国部分人发生的禽流感可能是通过家禽感染的;候鸟的迁徙在传播病毒过程中所起的作用有待深入探讨。 |
| 英文摘要: |
| After collecting the HA gene sequences of 42 strains of avian influenza viruses (AIV) H5N1 isolated from human (Homo sapiens),poultry and wild birds by searching the GenBank of NCBI,we analyzed the transformation of the amino acid residues at key sites and constructed the phylogenetic tree using DNAStar and compared the homology and evolutionary relationship of these HA genes.The results suggest that HA genes of these AIV H5N1 viruses varies persistently at different rates.Within the same area or neighboring areas in China,the nucleotides are more homologous in the same year or between the continuous two years,indicating that some human AIV diseases may have been caused by the H5N1 viruses infection from poultry.And more researches concerning the role of wild birds are needed. |
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