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Ndc80复合体在外层动粒中的作用
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国家973项目前期研究专项(No.2006CB708506)


Functions of Ndc80 Complex in Outer Kinetochore
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    摘要:

    动粒是参与有丝分裂过程中染色体分离的蛋白的附着支架。结构保守的Ndc80复合体位于动粒的外层,连接动粒和微管,与动粒-微管连接的稳定性有关。AuroraB/Ipl1激酶参与纠正动粒-微管的错误连接。Ndc80复合体对纺锤体组装检查点的功能非常重要。本文主要介绍了Ndc80复合体的研究进展。

    Abstract:

    Kinetochore is a protein scaffold coordinating the process of chromosome segregation in mitosis. The conserved Ndc80 complex is located on outer kinetochore to connect kinetochore with microtubules,and to stabilize the microtubule-kinetochore attachment. Aurora B /Ipl1 kinase parties involved in correcting the attachment errors. Ndc80 complex is also essential for the functions of spindle assembly checkpoint. This article reviews the current progress in Ndc80 complex studies.

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邢雪琨,徐存拴.2010. Ndc80复合体在外层动粒中的作用.动物学杂志,45(3):176-180.

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  • 收稿日期:2009-10-28
  • 最后修改日期:2010-02-26
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  • 通讯地址：北京 朝阳区 北辰西路1号院5号 中国科学院动物研究所
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