| 邢雪琨,徐存拴.2010.Ndc80复合体在外层动粒中的作用.动物学杂志,45(3):176-180. |
| Ndc80复合体在外层动粒中的作用 |
| Functions of Ndc80 Complex in Outer Kinetochore |
| 投稿时间：2009-10-28 修订日期：2010-02-26 |
| DOI： |
| 中文关键词: Ndc80复合体 动粒 微管 染色体 纺锤体组装检查点 |
| 英文关键词:Ndc80 complex Kinetochore Microtubule Chromosome Spindle assembly checkpoint |
| 基金项目:国家973项目前期研究专项(No.2006CB708506) |
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| 中文摘要: |
| 动粒是参与有丝分裂过程中染色体分离的蛋白的附着支架。结构保守的Ndc80复合体位于动粒的外层,连接动粒和微管,与动粒-微管连接的稳定性有关。AuroraB/Ipl1激酶参与纠正动粒-微管的错误连接。Ndc80复合体对纺锤体组装检查点的功能非常重要。本文主要介绍了Ndc80复合体的研究进展。 |
| 英文摘要: |
| Kinetochore is a protein scaffold coordinating the process of chromosome segregation in mitosis. The conserved Ndc80 complex is located on outer kinetochore to connect kinetochore with microtubules,and to stabilize the microtubule-kinetochore attachment. Aurora B /Ipl1 kinase parties involved in correcting the attachment errors. Ndc80 complex is also essential for the functions of spindle assembly checkpoint. This article reviews the current progress in Ndc80 complex studies. |
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