| 陈玉冬,邹志华,王艺磊,张子平.2010.vasa基因研究进展.动物学杂志,45(4):173-180. |
| vasa基因研究进展 |
| Progress in Studies of vasa Gene |
| 投稿时间：2009-12-22 修订日期：2010-04-26 |
| DOI： |
| 中文关键词: vasa VASA蛋白 DEAD-box 生殖细胞 配子发生 |
| 英文关键词:vasa VASA-protein DEAD-box Germ cells Gametogenesis |
| 基金项目:国家自然科学基金项目(No.30571430);福建省自然科学基金项目(No.2009J01179);集美大学创新团队基金项目(No.2008A001) |
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| 中文摘要: |
| DEAD-box家族基因编码一类ATP依赖的RNA解旋酶。经系统进化分析可将该家族蛋白分为VASA、PL10和p68三个亚家族。其中,vasa基因最先在果蝇(Drosophila melanogaster)中被发现,在许多动物中都已经克隆得到其同源基因,研究显示,vasa基因在生殖细胞系中特异性表达,在许多生物中为生殖细胞形成和配子发生所需。有趣的是在果蝇中VASA蛋白是生殖质的组成部分,而在斑马鱼(Danio rerio)中vasa mRNA才是生殖质的组成部分。本文主要综述了vasa基因及其蛋白的结构、功能、表达和作为原生殖细胞分子标记物的应用等方面的内容,并展望了其研究前景。 |
| 英文摘要: |
| DEAD-box family genes encode ATP-dependent RNA helicase proteins,which are divided into VASA,PL10 and p68 sub-families by phylogenetic analysis. vasa gene was firstly discovered in fruit flies (Drosophila melanogaster) and since then its homologous genes have been cloned in various animal species. Researches revealed a specific expression of vasa gene in the germ cells. The vasa gene is essential for germ cell formation and gametogenesis. Interestingly in fruit fly,VASA protein is a component of the germ plasm, while vasa mRNA is a component of the germ plasm in zebrafish (Danio rerio). In this paper,the structure, function,expression pattern and the application of the vasa gene as a molecular marker of primordial germ cells are reviewed,and the perspective of vasa gene studies is also introduced. |
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