| 蒲鲁鲁,张子平,王艺磊,陈芸.2011.硬骨鱼类雄激素受体研究进展.动物学杂志,46(4):150-160. |
| 硬骨鱼类雄激素受体研究进展 |
| Androgen Receptor in Teleosts |
| 投稿时间：2010-11-29 修订日期：2011-04-27 |
| DOI： |
| 中文关键词: 雄激素受体 基因结构 性别分化 配体亲和力 硬骨鱼 |
| 英文关键词:Androgen receptor Gene structure Sex differentiation Ligand-binding Teleost |
| 基金项目:国家自然科学基金项目(No.30600467),福建省科技重点项目(No.2008N0121),集美大学创新团队基金项目(No.2010A001) |
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| 中文摘要: |
| 在脊椎动物中,雄激素的生理作用主要是通过核雄激素受体(nuclear androgen receptor, nAR)介导的,这种转录因子属于核受体超家族成员。从哺乳动物到硬骨鱼类,均存在nAR。与高等脊椎动物不同的是,由于基因倍增等原因,部分硬骨鱼类 nAR 存在2种亚型。它们在鱼类胚胎发育和性腺发育过程中表现为不同的组织分布和表达类型。新近研究表明,雄激素也可以引起细胞的非基因组效应,即不通过经典的核受体做出反应,而是在质膜通过膜雄激素受体(membrane androgen receptor, mAR)来调节。本文就 nAR 的基因结构、分子生物学特性、组织分布、激素亲和力等方面的研究进行综述的同时,也对鱼类mAR的激素亲和特性、组织分布及其与生殖周期关系等方面的研究做了介绍。 |
| 英文摘要: |
| The biological activity of androgens is mediated by the nuclear androgen receptor (nAR) in vertebrates. nAR is a ligand-regulated transcriptional factor, which belongs to the nuclear receptor superfamily. nAR has been characterized from mammals to teleosts. The nAR subtype is found to exist in two different isoforms in several fish species due to a teleost specific gene duplication event. These subtypes of nAR form two distinct molecular clusters and display different tissue distributions and expression patterns during embryogenesis and gonad development. Recently, increasing evidence has shown the nongenomic or cell surface receptor (the membrane androgen receptor, mAR)-mediated actions of androgen. Here we review the gene structure; molecular and biological characteristics; tissue distribution; and ligand-binding features of nAR . Furthermore, we also review the characteristics, distribution and relationship of mAR with regards to the reproductive cycle in teleost fish. |
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