The effects of hypoxia exposure on contents of catecholamine and norepinephrine in serum between Myospalax cansus and SD rat (Rattus norregicus)were comparatively studied.Results showed that both catecholamine and norepinephrine in serum were increased at the initial phase of acute hypoxia (0.5-4.0 h). The catecholamine content in SD rat serum was significantly higher than that of M.cansus (P<0.05) under normoxic condition.After exposed to hypoxia for 6 hours,the contents of catecholamine and norepinephrine in SD rats were decreased sharply,and individuals died at 6.5 to 7.0 hours.But the contents of the two hormones in M.cansus serum were decreased with the increase of hypoxic duration.M.cansus showed strong adaptability in hypoxic environment.