陈婧,吴民耀,王宏元.2012.甲状腺激素在两栖动物变态过程中的作用.动物学杂志,47(6):136-143. |
甲状腺激素在两栖动物变态过程中的作用 |
The Role of Thyroid Hormone in the Amphibian Metamorphosis |
投稿时间:2012-04-26 修订日期:2012-09-11 |
DOI: |
中文关键词: 甲状腺激素 甲状腺激素受体 两栖动物变态 |
英文关键词:Thyroid hormone Thyroid hormone receptors Amphibian metamorphosis |
基金项目:中央高校基本科研业务费专项资金项目(No.GK261001) |
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中文摘要: |
两栖动物的幼体变态是研究甲状腺激素调节组织和器官重构的理想模式。本文主要综述了近年来两栖动物甲状腺激素合成过程中3种脱碘酶D1、D2和D3的特点及其生物学功能;甲状腺激素受体的蛋白结构、类型和机能;以及甲状腺激素对两栖动物幼体变态过程中各个类型组织和器官重构的调节;甲状腺激素、甲状腺激素受体和脱碘酶的互作,并展望了今后的研究方向。 |
英文摘要: |
Amphibian metamorphosis is an ideal model system to understand the action of the thyroid hormone (TH) on the remolding of tissue and organ. Firstly, the characteristics and functions of three types of deiodinases are reviewed. Emphasis is laid on the structure, the types and functions of thyroid hormone receptors. The remolding of tissue and organ in amphibian metamorphosis regulated by TH is described. Meanwhile, interactions among TH, deiodinase and thyroid hormone receptors in amphibian metamorphosis are discussed. Finally, future perspectives for amphibian metamorphosis studies are proposed. |
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