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王妍,周江,王义鹏,肖宁.2021.两栖类动物Cathelicidins家族 抗菌肽研究进展.动物学杂志,56(2):303-319.
两栖类动物Cathelicidins家族 抗菌肽研究进展
Research Progress of Cathelicidins Family Antimicrobial Peptides in Amphibians
投稿时间:2020-08-12  修订日期:2021-01-04
DOI:10.13859/j.cjz.202102015
中文关键词:  两栖类  Cathelicidins  抗菌肽  结构与功能  抗菌活性
英文关键词:Amphibian  Cathelicidins  Antimicrobial peptides  Structure  Function  antimicrobial activity
基金项目:中央引导地方科技发展资金项目(No. [2020] 4002),贵州省国家级地理学一流学科建设项目(No. [2017] 85-01),贵州省科技厅重点研发项目(No. [2017] 5411),科技部科技基础条件平台项目(No. 2005DKA21402),贵州省科技厅项目(黔科合基础[2016]1004)
作者单位E-mail
王妍 贵州师范大学生命科学学院 贵阳 550000 wangyan3wy@126.com 
周江 贵州师范大学生命科学学院 贵阳 550000 zhoujiang@ioz.ac.cn 
王义鹏 苏州大学药学院 苏州 215123 yipengwang@suda.edu.cn 
肖宁 贵阳护理职业学院 贵阳 550014 armiger@163.com 
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中文摘要:
      两栖类动物皮肤裸露和湿润的特性易于微生物的生长,它们为了抵御病原微生物的侵袭,在长期自然进化过程中形成了以抗菌肽(AMPs)为主要防御机制的免疫系统。抗菌肽广泛分布于动物、植物、微生物中,是生物用于抵御细菌、真菌、病毒和原虫等病原体侵袭的重要武器之一,在进化上是一类非常古老而有效的天然防御物质。Cathelicidins是脊椎动物特有的重要抗菌肽家族之一,除具有高效广谱的抗菌活性,还具有如抗炎、抗氧化、伤口修复、抑制组织损伤和促进血管生成等多种重要活性,因此Cathelicidins家族抗菌肽已成为抗感染多肽类新药的研发热点。本文将从两栖类动物Cathelicidins家族抗菌肽的一般特点、来源分布、生物合成与结构、生物学活性、作用机制及应用前景等几个方面,综合阐述国内外的研究动态。
英文摘要:
      The bare and moist characteristics of amphibian skin makes it prone to microbial infection. In order to resist the invasion of pathogenic microorganisms, amphibians form an immune system with antimicrobial peptides as the main defense effector during the long-term natural evolution. Antimicrobial peptides (AMPs) are widely distributed in animals, plants and microorganisms, which are pivotal weapons for host to resist bacteria, fungi, viruses and protozoa. AMPs represent very ancient and effective natural defense substances in evolution. Cathelicidins are an important family of AMPs exclusively existing in vertebrates, and they are also one of the most powerful family of AMPs known to date. Cathelicidins have been identified in most kinds of vertebrates. In addition to potent and broad-spectrum antimicrobial activities, they also possess many other important activities such as anti-inflammation, anti-oxidation, wound repair, tissue damage inhibition and angiogenesis promotion. As a result, Cathelicidins are becoming a hot spot of anti-infective peptide agent development. There is a large amount of amphibian species in nature, which contain many novel Cathelicidins family AMPs with diverse structures and functions. Therefore, it is of great significance to study amphibian Cathelicidins for animal immunology research and drug development. The present article comprehensively reviews the research progress of amphibian Cathelicidins from the aspects of general characteristics, source distribution, biosynthesis and structures, biological activities, mechanisms of action and application prospects.
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