The study was designed to explore the distribution and shape of the 5-hydroxytryptamine (5-HT) cells, the somatostatin (SS) cells and the gastrin (GAS) cells in the stomach of Siberian Salamander (Salamandrella keyserlingii) during the post-embryonic development (from the stages 41 to 46) by avidin-biotin complex methods (ABC). The results indicated that the 5-hydroxytryptamine cells and the gastrin positive cells were firstly found in the stomach at the 41st stage. Then the somatostatin positive cells were detected at the 42nd stage. Statistic analysis of the same endocrine cells at different stages to in the stomach showed that the 5-hydroxytryptamine cells were found the least at the stage 41 (1.2 ± 0.51) by Duncan methods, and the most at the stage 46 (2.3 ± 0.91). With the development of stomach of Siberian Salamander, the 5-hydroxytryptamine cells showed an increasing trend. The gastrin cells were most widely distributed at the stage 42 (2.1 ± 0.99), followed by the stage 46 (1.7 ± 0.49) and the distribution quantity was the least at the stage 44 (1.0 ± 0.00). Their distribution trend from the stages 42 to 46 was first decrease and later increase. The density distribution of the somatostatin cells was the highest at the stage 43 (2.6 ± 0.99) exceeding the rest stages, with significant difference (P < 0.05, Table 1). Three kinds of endocrine cells firstly appeared among the epithelium cells, and with the development of stomach they distributed among the acinar epithelial cells (PlateⅠ). The morphology of endocrine cells varied in different development stages, such as the shapes of 5-hydroxytryptamine cells were from the round to the cone, the shapes of gastrin cells were from the cone to round then to cone, and the shapes of somatostatin cells were from the cone to the ellipse. The distribution and shape characteristics of these endocrine cells may adapt to the growth and development of Siberian Salamander and the function of the stomach.