The pathological anatomy and hitopathology of diseased Chinese Giant Salamander (Andrias davidianus) infected by Pseudomonas fluorescents were examined. The results showed that the diseased fish had extremely swelling abdomen with severe vomiting (Fig. 1a). Some stomachs even reached mouth due to vomitting (Fig. 1b). The serious lesions occurred in the kidney, liver, intestine, skin and muscle, causing necrotic glomerular nephritis and hepatitis, and mild enteritis and dermatitis. Renal tubular epithelial cells showed severe edema and big vacuoles in the cytoplasm (Fig. 2c). Urinary cylinder in kidney tubules (Fig. 2a), renal interstitial capillary congestion (Fig. 2b) and eosinophils infiltration in renal interstitial (Fig. 2d) could also be observed. A large number of bacteria appeared in the tubular lumen (Fig. 2e). Hepatic cells showed severe edema (Fig. 2f) and enlargement with a large number of bacilli (Fig. 2g﹣h). Lysis also appeared in the liver. Lamina propria showed severe edema (Fig. 2i) infiltrated with bacilli (Fig. 2j). Capillary congestion and inflammatory cell infiltration were observed in epidermis (Fig. 2k). Also, a large number bacilli existed in the muscle tissue (Fig. 2l).