首页 > 过刊浏览>2017年第52卷第4期 >717-725. DOI:10.13859/j.cjz.201704023
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哺乳动物季节性繁殖的内源年生物钟及光敏神经环路研究进展
作者:
作者单位:

1安徽大学 健康科学研究院 合肥 230601 中国;② 中国科学院动物研究所 农业虫害鼠害综合治理研究国家重点实验室 北京 100101 中国,中国科学院动物研究所 农业虫害鼠害综合治理研究国家重点实验室 北京 100101 中国,② 中国科学院动物研究所 农业虫害鼠害综合治理研究国家重点实验室 北京 100101 中国

基金项目:

国家自然科学基金项目（No. 31470474，31270010）


Molecular Basis of Annual Clock and Photosensitive Neural Circuits for Regulating Seasonal Reproduction in Mammals
Author:
Affiliation:

State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing,State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing

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    摘要:

    生活在温带和寒带的哺乳动物在长期的进化过程中形成了季节性繁殖的生活史特征。哺乳动物的繁殖功能主要受到下丘脑-垂体-性腺轴（hypothalamic-pituitary-gonadal axis，HPGA）的调控。视交叉上核（suprachiasmatic nucleus，SCN）能够自发振荡并响应光周期信号的变化，引发褪黑素分泌的改变，并介导下游通路中下丘脑甲状腺激素、Kisspeptin和RF酰胺相关肽（RF amide-related peptide，RFRP）的节律性表达变化，从而调控哺乳动物的季节性繁殖。本文综述了哺乳动物季节性繁殖的内源年生物钟调控，并强调了光敏通路中包括甲状腺激素、Kisspeptin和RFRP在季节性繁殖调控中的重要作用。

    Abstract:

    Seasonal reproduction is a common life history strategy evolved by mammals inhabiting in temperate and arctic zones. This physiological process is controlled by hypothalamic-pituitary-gonadal axis (HPGA). As a circadian pacemaker, the suprachiasmatic nucleus (SCN) could oscillate spontaneously and respond light entrainment, then trigger rhythmic changes of melatonin, hypothalamic thyroid hormone, Kisspeptin as well as RFamide-related peptide (RFRP) to regulate the annual cycle from anestrus to reproduction. This review summarized the current understanding on annual clock and photosensitive neuronal circuits for regulating seasonal reproduction, and emphasized the significance of circadian clock, thyroid hormone, Kisspeptin, and RFRP.

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姚蔚,王德华,张学英.2017.哺乳动物季节性繁殖的内源年生物钟及光敏神经环路研究进展.动物学杂志,52(4):717-725.

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  • 收稿日期:2016-12-12
  • 最后修改日期:2017-06-20
  • 录用日期:2017-06-13
  • 在线发布日期: 2017-07-17
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