In order to achieve hemosiderosis,the rats were fed with iron-supplemented diet or injected with iron polysaccharide complex intraperitoneally(i.p.) or intravenously(i.v.).Hemosiderin deposit was detected in the sclera,iris,ciliary body,and interstitial connective tissue of the choroid and macrophages lying in the interlobular connective tissue of lacrimal glands in all animals that received iron i.v.Also,little or no iron deposit was detected in the eye and lacrimal glands in animals that received iron i.p.and in individuals that were fed with an iron-enriched diet and the control rats.No transferrin was detected in the eye and lacrimal glands,either in the control rats or in the rats received iron.Therefore,iron deposition may be responsible for the ophthalmologic abnormalities in hemosiderosis syndromes,such as lens opacities and angioid streaks.