Comparisons on the length and mass of digestive organ, morphological feature and distributive density of argyrophilic cells along the gastrointestine of Cynops orientalis were performed between feeding and fasting groups (15 days) by means of Longguikai’s sliver staining method. As compared with feeding group, fasting individuals showed reduced intestine mass and shorter stomach length. Argyrophilic cells showed various morphological features in both feeding and fasting groups, and they were round, oval, wedge-like, cone-like, inkbrush-like, and tadpole-like in shape. Distributive density of argyrophilic cells along the gastrointestine in feeding group showed the highest in the pylorus, and the lowest in the duodenum; Distributive density of argyrophilic cells along the gastrointestine in fasting group showed the highest in the cardia, and the lowest in the duodenum, ileum and rectum. The distributive density of cells in any other segment of gastrointestine except for the pylorus and duodenum in fasting group was higher than that in feeding group. The results show that fasting treatment can increase the density of argyrophilic cells in the front and post portions of the gastrointestine, which may be related to the feeding habit and capacity of enduring starvation for a longer phase in C.orientalis.