The construction of Three Gorges Project results in water current slow down and enlarges the area of mudflat which is along the Yangtze River and its main tributaries submerges periodically.The changed environment might favor the survival and dispersal of Oncomelania hupensis who is the host of Schistosoma japonicum.In this paper,we predicted the possible influence of climate data,vegetation and the periodically flooded on O.hupensis survival and dispersal in submerged mudflat based on the life history of O.hupensis using 1∶50 000 and the 1∶10 000 DEM of the study area.The climatic condition and flood period in the study area is possible to meet their requirement.However,the life history of O.hupensis is not matched with the time schedule of the Three Gorges Reservoir impounding water in winter and disembogue water in summer.Therefore,the construction of the project would not increase the possibility of O.hupensis survival and dispersal in the study area.