长期强迫运动对大绒鼠体重、能量代谢和血清瘦素的影响
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国家自然科学基金项目(No.31071925);云南省应用基础研究面上项目(No.2011FZ082)


Effects of Long-term Forced Exercise Training on Body Mass, Energy Metabolism and Serum Leptin in Eothenomys miletus
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    摘要:

    动物稳定体重的维持需要能量摄入和消耗之间的平衡。运动是影响动物能量平衡的重要因素之一。为了解运动对大绒鼠(Eothenomys miletus)的生理学效应,在室内条件下,测定了强迫运动训练(运用小鼠封闭跑台)8周后大绒鼠的体重、代谢率、摄入能、血清瘦素和身体组成的变化。结果显示,强迫运动训练8周对大绒鼠的体重无显著影响;大绒鼠的代谢率和摄入能均显著增加,训练8周后静止代谢率较对照组增加了29.9%,运动最大代谢率较对照组增加了10.7%;强迫运动训练8周组的身体脂肪重量比对照组降低了28.9%,血清瘦素水平比对照组下降了27.4%,对照组的瘦素与体脂含量具有明显的相关性,但运动组则不具有相关性;运动组的肝重量和消化道重量较对照组均显著增加;而体水重量则显著降低。这些结果表明,在强迫运动训练期间大绒鼠主要通过动员储存的脂肪、增加代谢率和食物摄入的方式来维持自身的体重及能量平衡。瘦素在长期强迫运动过程中对身体脂肪含量的变化具有调节作用。

    Abstract:

    Animal requires a balance between energy intake and energy expenditure to maintain a stable body weight. Exercise which can increase energy expenditure is one of the most important factors affecting energy balance for animals. In order to understand the physiological effects of exercise, changes of body mass, metabolic rate, energy intake, serum leptin and body composition were measured in Eothenomys miletus during 8-weeks of forced exercise training with of treadmill. The results showed that exercise training had no significant effects on body mass, but the metabolic rate and energy intake were increased during 8-weeks exercise training, rest metabolic rate increased 29.9% and locomotor maximal metabolic rate increased 10.7%, respectively. The results also showed that exercise training decrease body fat by 28.9% compared with control group, and exercise training decrease serum leptin concentrations by 27.4% compared with control group. There was a positive relationship between serum leptin concentrations and body fat content in control group, but no for exercise trained group. There were significant increase of the mass of liver and digestive tracts compared with control group, and significant decrease of body water content compared with control group. All results indicated that E.miletus regulates its body mass and energy balance through mobilizing body fat, increasing the metabolic rate and energy intake during long-term forced exercise training. Serum leptin can regulate the variation of body fat during long-term forced exercise training.

    参考文献
    [1] 李玉莲, 战新梅, 刘秀珍, 等. 长期强迫运动对布氏田鼠体重和血清瘦素浓度的影响. 兽类学报, 2008, 28(2): 151-156.
    [2] Levin B E, Dunn-Meynell A A. Chronic exercise lowers the defended body weight gain and adiposity in diet-induced obese rats. Am J Physoil Regul Integr Comp Physiol, 2004, 286(4): R771-R778.
    [3] Kawaguchi M, Scott K A, Moran T H, et al. Dorsomedial hypothalamic corticotropin-releasing factor mediation of exercise-induced anorexia. Am J Physoil Regul Integr Comp Physiol, 2005, 288(6): 1800-1805.
    [4] Kimura M, Tateishi N, Shiota T, et al. Long-term exercise down-regulates leptin receptor mRNA in the arcuate nucleus. Neuroreport, 2004, 15(4): 713-716.
    [5] Gattermann R, Weinandy R, Fritzsche P. Running-wheel activity and body composition in golden hamsters (Mesocricetus auratus). Physiol Behav, 2004, 82(2/3): 541-544.
    [6] 胡振东, 姚雪, 王德华. 自愿转轮运动对长爪沙鼠身体组成的影响. 动物学杂志, 2007, 42(5): 1-7.
    [7] Miyasaka K, Ichikawa M, Kawanami T, et al. Physical activity prevented age-related decline in energy metabolism in genetically obese and diabetic rats, but not in control rats. Mech Ageing Dev, 2003, 124(2): 183-190.
    [8] Allen D L, Harrison B C, Maass A, et al. Cardiac and skeletal muscle adaptations to voluntary wheel running in the mouse. J Appl Physiol, 2001, 90(5): 1900-1908.
    [9] Momken I, Lechêne P, Ventura-Clapier R, et al. Voluntary physical activity alterations in endothelial nitric oxide synthase knockout mice. Am J Physiol Heart Circ Physiol, 2004, 287(2): H914-H920.
    [10] Perrin M R, Richardson E J. Metabolic rate, maximum metabolism, and advantages of torpor in the fat mouse Steatomys pratensis natalensis Roberts, 1921 (Dendeomurinae). Journal of Thermal Biology, 2005, 30(8): 603-610.
    [11] Chappell M A, Hammond K A. Maximal aerobic performance of deer mice in combined cold and exercise challenges. J Comp Physiol B, 2004, 174(1): 41-48.
    [12] Silva J E. Thermogenic mechanisms and their hormonal regulation. Physiol Rev, 2006, 86(2): 435-464.
    [13] Zhang Y Y, Proenca R, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue. Nature, 1994, 372(6505): 425-432.
    [14] Friedman J M, Halaas J L. Leptin and the regulation of body weight in mammals. Nature, 1998, 395(6704): 763-770.
    [15] Bates S H, Myers M G. The role of leptin-STAT3 signaling in neuroendocrine function: an integrative perspective. J Mol Med, 2004, 82(1): 12-20.
    [16] Barb C R, Hausman G J, Houseknecht K L. Biology of leptin in the pig. Domest Anim Endocrinol, 2001, 21(4): 297-317.
    [17] Barb C R, Kraeling R R. Role of leptin in the regulation of gonadotropin secretion in farm animals. Anim Reprod Sci, 2004, 82-83: 155-167.
    [18] 胡振东, 王德华. 自愿转轮运动条件下雌性长爪沙鼠的体重、能量代谢和血清瘦素含量的变化. 中国运动医学杂志, 2007, 26(5): 605-608.
    [19] 胡振东, 王德华. 自愿转轮运动对雄性长爪沙鼠体重和能量代谢的影响. 兽类学报, 2007, 27(2): 123-129.
    [20] 郑少华. 川黔地区第四纪啮齿动物化石. 北京: 科学出版社, 1993.
    [21] 朱万龙, 杨永宏, 贾婷, 等. 横断山两种小型哺乳动物的蒸发失水与体温调节. 兽类学报, 2008, 28(1): 65-74.
    [22] 王政昆, 孙儒泳, 李庆芬, 等. 中缅树鼩静止代谢率的研究. 北京师范大学学报: 自然科学版, 1994, 30(3): 408-414.
    [23] Hill R W. Determinat汩獯?椠湯?栠畯浸慹湧獥?????灳灵汭?側桩祯獮椠潢汹???????????ㄠ??????で??扴物?嬠??嵹??楮挠歡敮祡???卥???慊氠獁扰数敬欠??????偬氬愠猱洹愷′氬攠瀳琳椨渲?愺渠搲?攱砭攲父挳椮猼敢? ̄牛攲挴敝渠琱?暙椬渠搾楷測朠獎??匬瀠潉爮琠玷??敡擶????や???????????????????戰爸?嬠??崨??漺稠椵渹漰瘭椶挰????卲挾慛氲椵湝朠?潥智?扮慤獥愠汅?慌測搠?浨慡硰楰浥畬浬?浍攠瑁愬戠潇汯業捥?爠慆琠敒?椠湥?爠潡摬攮渠瑍獡?慩湭摡?琠桭敥?慡敢牯潬扩楣挠?捡慴灥慳挠楤瑵祲?浮潧搠敶汯?晵潮牴?瑲桹攠?數癥潲汣畩瑳楥漬渠?潯晲?敥湤搠潥瑸桥敲牣浩祳??倠桡祮獤椠潣汯?婤漠潥汸????????????????????????扥牣?孩??嵬??晢潲湥獤漠?噯?????楨欠敷汨扥潥潬洭?創??剩敮汧愮琠楊潯湵獲桮楡灬?扯敦琠睅數数湥?睩桭敥敮汴?牬甠湂湩楯湬杯??昬攠攲搰椰渵本?′搰爸椨渱欲椩渺朠??愴渷搭′戴漵搸礮?睢敲椾杛栲琶?椠湒?浳慥汮敭?牮慮琠獍??偍桯祲獲楩潳汯??敐栮愠癍???ねふ????べ????????????扩牯?嬠??嵤??敥獡杴漠牬捯敳獳???????桴敡湴湩慯潮甠楩?????潬浬攠穨??敥牯楴湨潥????敢瑹?慈汥???敳灵瑢椾渲?爯敳獵灢漾渮猠敁?琠潊?慐捨畹瑳敩?灬爬漠氱漹渷朴攬搠′攲砶攨爳挩椺猠攴?愰昭琴改爵?琼牢慲椾湛椲渷杝?楌湩?牘漠睓攬爠獗???甠牄????灒灥汧?偬桡祴獩楯潮氠??㈠ぢは?????????????????????扥牮?孳?び崠??攠牳瑥楡湳杯?呡?????潣杣畬敩??????剤攠獂灲潡湮獤整猠?漠晳?瑶桯敬?杳甠琨?瑥潭 ̄浍潩摣敲牯慴瑵敳?敢湲敡牮杤祴?搼支浥慭渾搩献?楈湯?慭?獂浥慨污汶?栠攲爰戰椵瘬漠爴攸???攺洠??椱挭爳漲琸甮猼?灲放湛渲猸祝氠療慡湲楴据略獳??敔洠???????愠浇洠??ㄠ??????????????????intake and energy regulation in exercising and melatonin-treated Siberian hamsters. Physiol Behav, 1985, 35(5): 805-808.
    [29] Coutinho A E, Fediuc S, Campbell J E, et al. Metabolic effects of voluntary wheel running in young and old Syrian golden hamsters. Physiol Behav, 2006, 87(2): 360-367.
    [30] Simsch C, Lormes W, Petersen K G, et al. Training intensity influences leptin and thyroid hormones in highly trained rowers. Int J Sports Med, 2002, 23(6): 422-427.
    [31] Richard D, Rivest S. The role of exercise in thermogenesis and energy balance. Can J Physiol Pharmacol, 1989, 67(4): 402-409.
    [32] Miyasaka K, Ichikawa M, Kawanami T, et al. Physical activity prevented age-related decline in energy metabolism in genetically obese and diabetic rats, but not in control rats. Mech Ageing Dev, 2003, 124(2): 183-190.
    [33] Narath E, Skalicky M, Viidik A. Voluntary and forced exercise influence the survival and body composition of ageing male rats differently. Exp Gerontol, 2001, 36(10): 1699-1711.
    [34] Fridman J M. The function of leptin in nutrition, weight, and physiology. Nutr Ren, 2002, 60(10): S1-S14.
    [35] Pérusse L, Gollier C, Gagnon J, et al. Acute and chronic effects of exercise on leptin leve
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朱万龙,王政昆,杨盛昌,张麟.2012.长期强迫运动对大绒鼠体重、能量代谢和血清瘦素的影响.动物学杂志,47(4):28-35.

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  • 收稿日期:2011-12-06
  • 最后修改日期:2012-02-25
  • 在线发布日期: 2012-08-16