Excessive deposition of fat will lead to various diseases, such as heart disease, hypertension,hypertriglyceridemia, type Ⅱ diabetes etc. Mice (Mus musculus) and porcine (Sus domesticus) are commonly used models for studying lipid accumulation, but more and more researches show that lipid deposition is a very complex physiological process involving in various regulation networks of fat metabolism. Many key fat regulatory genes and fat metabolism pathways found in mammals are conserved in Caenorhabditis elegans. Therefore,C.elegans is a powerful genetic model for fat biology research. This article summarizes the progress of fat deposition in C.elegans.