Amphibian metamorphosis is an ideal model system to understand the action of the thyroid hormone (TH) on the remolding of tissue and organ. Firstly, the characteristics and functions of three types of deiodinases are reviewed. Emphasis is laid on the structure, the types and functions of thyroid hormone receptors. The remolding of tissue and organ in amphibian metamorphosis regulated by TH is described. Meanwhile, interactions among TH, deiodinase and thyroid hormone receptors in amphibian metamorphosis are discussed. Finally, future perspectives for amphibian metamorphosis studies are proposed.