[Objectives] Cipangopaludina chinensis is widely distributed in Asia. It has strong adaptability and can quickly enter a dormancy state under drought.In this paper, we study the dormancy characteristic of C. chinensis under drought stress to provide a research clue for revealing the mechanism of extensive adaptive tolerance, as well as the genetics and breeding of the C. chinensis. [Methods] The samples of C. chinensis were collected in Yancheng. Select individuals with sound ontogeny and consistent size to temporarily keep in the laboratory for 2 days. 30 C. chinensis were placed in an anhydrous plastic bucket for drought stress treatment, and the room temperature was adjusted to 24 ℃. 30 C. chinensis were placed in plastic buckets with water as control, and kept temporarily for 30 days. After 30 days, the liver and kidney tissues of the control group and the stress group were taken at random for 3 biological replications. High throughput sequencing technology was used to sequence and analyze the transcriptome of the liver and kidney tissues of C. chinensis under drought stress. After cleaning the raw sequencing datathen we identified different expressed genes by P < 0.05 and | log2FoldChange | > 2. Finally, GO (gene ontology) annotation and pathway enrichment analysis of the different expressed geneshave been done. [Results] The results showed that under drought stress, 110 genes were up-regulated and 389 genes were down regulated in the kidney tissue, 84 genes were up-regulated, and 86 genes were down-regulated in the liver tissue (Fig. 3), gene ontology is mainly related to the regulation of cell adhesion, extracellular matrix organization, neuron projection regeneration, carbohydrate metabolic process, dephosphorylation, regulation of epithelial cell proliferation, carboxylic acid, organic acid transmembrane transport, and tissue remodeling (Fig. 5); the KEGG enrichment analysis showed that the differently expressed genes were mainly enriched in PI3K-Akt signal pathway, proteoglycan, lactose, sphingolipid biosynthesis and metabolic pathway 5 that are the main pathways under drought stress (Fig. 6). [Conclusion] Based on the enrichment analysis results of GO and KEGG, heat shock protein genes Hsp70, SRCR, SLC28A3, FASN, APMAP, MSTN, Poc1b, S1P and Na⁺- K⁺- ATPase β Subunit 1 have been identified as important genes related to dormancy of the C. chinensis under drought stress.