[Objectives] The Snow Leopard Panthera uncia is one of the world’s rare and endangered species and is vital in maintaining alpine ecosystems’ structural and functional stability. In recent years, grazing and other disturbances have led to the fragmentation of the Snow Leopard’s habitat and threatening the population’s survival. In order to protect and recover this species, conducting habitat suitability evaluation and building ecological corridors that connect scattered patches of habitat are essential for safeguarding its long-term survival. [Methods] The study area of this research are the Qilian Mountain National Park (Gansu area) and its 15 km buffer zone. A predictive habitat distribution map of Snow Leopards was estimated using the MaxEnt model with a total of 64 occurrence locations (Fig. 1) which were collected by camera monitoring and survey between 2018 and 2020 and environmental factors. The distribution of potential habitat and its relationship with major environmental factors were analyzed with MaxEnt 3.4.1. The accuracy of the result produced by the model with area was evaluated by receiver operating characteristic, ROC (area under the curve, AUC). The importance and contribution of environmental factors to the model’s prediction were evaluated by the Jackknife test. Suitable habitat distribution was indicated by habitat suitability index (HSI). Ecological corridors for Snow Leopards were identified and planned using the least-cost path model (LCP). [Results] The results of the Jackknife test showed that three variables, roughness, mean temperature of driest quarter, and precipitation seasonality were the key factors influencing the distribution of Snow Leopards (Fig. 3), with a value of contribution of 45.936%, 17.078% and 11.519%, respectively (Table 1). The suitable habitat was positively correlated with the roughness, and the occurrence probability of Snow Leopards remained unchanged when the roughness exceeded about 200. The relationship between suitable habitat and mean temperature of driest quarter and precipitation seasonality were humped (Fig. 4). The suitable habitat area of Snow Leopards in the study area was 13 432.066 km², and the suitable habitat distributed in the park was 7 086.195 km2, accounting for 52.756% of the total suitable habitat area (Fig. 5b). According to habitat suitability analysis and population distribution of Snow Leopard, 9 core habitat patches were identified and 10 potential ecological corridors for Snow Leopard migration were delineated. The longest corridor length was 18.725 km, and the average length was 5.676 km (Fig. 6). Three of these corridors connected suitable Snow Leopard habitat patches within the Gansu area, and five connected the habitat in the Qinghai area. [Conclusion] Based on the results mentioned above, we recommend that efforts should be undertaken to enhance the connectivity between suitable habitats for Snow Leopards. Concurrently, it is advised to collaborate with Qinghai Province to facilitate cross-border conservation initiatives and develop a more scientifically sound and rational plan for protection and management.